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Emergency Department Pharmacy

Thrombolysis for massive PE in cardiac arrest

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Thrombolysis for massive PE in cardiac arrest

What is the consensus on thrombolysis dosing for massive PE when the patient is in cardiac arrest? BTS advise a single "50mg dose of Alteplase as an IV bolus followed by unfractionated heparin after 3 hours" Is this what is used in all Emergency Departments, as I've seen some trial data which used an initial 50mg IV bolus followed by an infusion of a further 40mg IV alteplase over 2 hours?
What is the consensus on thrombolysis dosing for massive PE when the patient is in cardiac arrest? BTS advise a single "50mg dose of Alteplase as an IV bolus followed by unfractionated heparin after 3 hours" Is this what is used in all Emergency Departments, as I've seen some trial data which used an initial 50mg IV bolus followed by an infusion of a further 40mg IV alteplase over 2 hours? (less...)
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